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Average weight loss in a 2022 study, for example, was 5.9% at the three month mark and 10.9% at six months

These findings are consistent with data accessed on August 25, 2025

Anaesthesia, 61(10), 1013-1014

If the weight is coming off too quickly, you may need to downregulate a dose or perhaps switch to a medicine thats less potent. Siegel points out that the lower 4 mg retatrutide dose yielded a 19 percent body weight reduction, with a significantly lower rate of discontinuation, suggesting this may be a more tolerable option for many