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Oxidative stress is associated with induction of neurosteroid biosynthesis in the human brain (284), and TSPO ligands ( N , N -dialkyl-2-phenylindol-3-ylglyoxylamides) that also show anxiolytic activity promote a reduction in oxidative stress and pro-inflammatory enzymes in glial cells via promotion of neurosteroid synthesis (133)

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DM2 en 55%), mostrando mejoras significativas en la fraccin de grasa heptica, transaminasas, el marcador de fibrognesis PRO-C3 y en parmetros metablicos despus de 19 semanas de tratamiento con 600mg de cotadutida frente a placebo26