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Additionally, proteomic analysis of complexes associated with activated integrins indicates that these complexes are enriched for proteins associated with microtubule stabilization at the cell cortex including, EB1, IQGAP, mDia, CLASPs, and LL5, (similar to LL5, further supporting the role of integrins in microtubule stabilization [59]

While it is generally accepted that opioid withdrawal is not fatal, iatrogenic precipitated withdrawal may be much more severe resulting in clinically significant autonomic hyperactivity with consequences such as pulmonary edema and make patients more reticent to continue with future medication for opioid use disorder

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