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It takes approximately 4 to 5 half-lives for plasma concentrations to reach about 97% of their final steady-state value .8 Factors Influencing the Level of C ss While the time to reach steady state is dependent only on half-life, the level or magnitude of the steady-state concentration is determined by the balance between the dosing rate and the drug's clearance

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However, intramuscular shots release B12 gradually from muscle tissue, while IV infusions deliver the full dose into the bloodstream immediately

References, sources and studies used alongside our own in-house research have been cited below, most of which contain external clickable links to reviewed scientific paper that contain date stamped evidence