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Numerous studies have demonstrated the therapeutic potential of phytomolecules in preclinical cellular and animal PD models, with their ability to exert pleiotropic neuroprotective effects by targeting, inflammatory signaling, mitochondrial dysfunction, S aggregation, and key pathways including sirtuins and PI3K/Akt signaling ( Future research should also aim to disentangle the mechanistic interplay between S accumulation, sirtuin dysregulation, and impaired insulin signaling in PD, to identify which phytomolecules are most effective in counteracting mitochondrial stress, mitophagy defects, and neuronal apoptosis

Initiation of a GLP-1 receptor agonist was associated with reduced risk of composite endpoint of all SUDs (hazard ratio 0.86 (0.83 to 0.88), NRD 6.61 (7.95 to 5.26)) (fig 3, fig 4 and supplementary table S6)

These foods can worsen several semaglutide side effects , including nausea, diarrhea, constipation , and vomiting

Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide, dulaglutide, and liraglutide, are widely prescribed in the UK for type 2 diabetes and obesity