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Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats

This maleimidopropionic acid sometimes called the drug affinity complex (DAC), forms stable covalent linkages with free thiol groups on the surface of plasma proteins such as serum albumin[1]

To directly evaluate the head-to-head weight-lowering potential of semaglutide versus GLP-1MK-801, we performed single intracerebroventricular (i.c.v.) infusions of equimolar concentrations of GLP-1MK-801 or semaglutide (Fig