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The exact pathophysiology involves increased intraluminal pressure, weakening of the colonic wall, and alterations in gut microbiota, though the precise mechanisms remain under investigation

Current evidence suggests dulaglutide (Trulicity) and extended-release exenatide (Bydureon) generally demonstrate lower nausea rates (approximately 8-12% at lower doses) compared to twice-daily exenatide or higher-dose semaglutide and liraglutide used for weight management

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These conditions can affect how the medication is absorbed and utilized by the body, so it is crucial for patients to disclose their medical history to ensure safe and effective treatment