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Eur J Pharmacol 606:262268 Zhou JY, Zhou SW, Zhang KB, Tang JL, Guang LX, Ying Y, Xu Y, Zhang L, DD, Li DD, (2008) Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats

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Indeed, a study in PubMed Central notes that rapid drop in body volume from GLP-1 drugs can reduce skin elasticity