During the clinical trial, the observed side effects were mainly gastrointestinal, such as nausea and vomiting
Whilst mutations of the MC4R are a rare genetic cause of obesity, the treatment of two people with POMC deficiency with the MC4R agonist setmelanotide previously resulted in massive weight loss of 51.0 kg and 20.5 kg over 42 and 12 weeks respectively [97], highlighting the potential of this mechanism to support weight loss in obesity
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And of course, it depends on the type of surgery that she's had
