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Warning signs requiring immediate medical attention include severe abdominal pain (especially radiating to the back or right upper quadrant), persistent vomiting preventing oral intake, fever, jaundice, or signs of dehydration

Balance between on- and off-target effects of the dual GLP1/E agonist, and the concurrence of desensitization at very high doses, might contribute to this phenomenon

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Vitamin B6 (Pyridoxine) : Supports brain health by creating mood-regulating chemicals like dopamine and serotonin