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Ethics statement The animal study was approved by Ethics Committees of Animal Experimentation of the Peoples Hospital of Wuhan University

Recent Phase 2 clinical data from the BMT-801 study demonstrated that PT-141 co-administered with the GLP-1/GIP agonist tirzepatide produces synergistic effects on weight loss

Conversely, administration of exendin-9 into the lateral septum increases food intake, prevents the ability of nutrient load to suppress food intake [165], prevents stress-induced hypophagia [166], and increases the motivation to obtain a sucrose reward [167]

One of these antioxidant defense systems is the glutathione antioxidant pathway, which includes the enzymes GPx, GST and GR, together with GSH metabolite