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Acute kidney injury due to volume depletion has been reported in postmarketing reports occurring in patients who experienced nausea, vomiting, or diarrhea, leading to dehydration

They are both particularly susceptible to oxidative stress due to the high percentage of oxygen required for healthy brain function

LA maintains the cellular antioxidant state indirectly through activating the NRF2 pathway, and the NRF2 pathway governs the expression of antioxidant genes (such as -glutamylcysteine synthetase (-GCL), NAD(P)H quinone oxidoreductase 1 (NQO-1), and superoxide dismutase (SOD)) for enhancing the cell's antioxidant capacity and anti-inflammatory response [34, 35]

Nilotinib is an orally available inhibitor of the BCR-ABL kinase and works by preventing the growth and proliferation of cancer cells, in turn inducing their death