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PAP blocks the NF-B signaling pathway to downregulate the expression of pro-inflammatory cytokines such as TNF- and IL-6, inhibiting the neuroinflammatory cascade, while also inhibiting the hypoxia stress signals mediated by HIF-1, reducing abnormal secretion of VEGF, thereby decreasing vascular permeability and the risk of brain edema (Shi J

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Rhim HC, et al