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Although global Thbs1 KO mice show significant defects in host defense during acute PA pneumonia when compared to WT mice 19,32 , a more modest phenotype was observed in PF4 C re Thbs1 flox KO mice, suggesting that additional cellular sources of TSP1 contribute to pulmonary host defense
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Animal care was in compliance with standard operating procedures (SOPs) of the Animal Pharmacology Facility and the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (ETS 123)
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