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7nAChRs are found in both presynaptic and postsynaptic sites, where they enhance the release of neurotransmitters

Deletion of amino acid transporter ASCT2 (SLC1A5) reveals an essential role for transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to sustain glutaminolysis in cancer cells

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Side effects or overdose effects are rare, but are limited to mild gastrointestinal signs, immediate post pill nausea and food refusal.Concomitant use of SAMe with tramadol, meperidine, dextromethorphan, pentazocine, MAOIs (selegiline), SSRIs (fluoxetine), other antidepressants (amitriptyline, clomipramine) may theoretically cause additive serotonergic effects