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Symptoms can range from mild discomfort, such as sneezing or itching, to more severe reactions, like anaphylaxis
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The leap from "complementary mechanisms in animals" to "effective and safe synergy in humans" has not been made by the evidence
Women who have had a previous NTD-affected pregnancy may be advised to consume up to 5 mg/day (5,000 g/day) of folic acid if they are planning a pregnancy, but this level of supplementation should be prescribed by their medical provider (see the CDC recommendations and the World Health Organization [WHO] guidelines)
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