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The effects of statins on Tregs in RA patients in vivo and in vitro confirm that Tregs participate in the immunomodulatory impact of statins on RA [152]
All animal procedures conformed to the UK legislation Animals (Scientific Procedures) Act 1986 (United Kingdom) and the University of Oxford Ethical Review Committee policy, with a final ethical review by the Animals in Science Regulation Unit (ASRU) of the UK Home Office
In addition to their insulinotropic effects, GIP and GLP-1 play critical roles in various biological processes in different tissues and organs that express GIPR and GLP-1R, including the pancreas, fat, bone and the brain
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