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10.1530/eje-07-0450 [DOI] [PubMed] [Google Scholar] 42.Smith J, Brown RS

Pharmacologic approaches to glycemic treatment: Standards of care in diabetes2023

Ferroptosis ensues when the physiological ferroptosis defense glutathione peroxidase 4 (GPX4) (which employs reduced glutathione) is overridden, resulting in the release of lipid peroxidation breakdown products such as malondialdehyde (MDA) and 4-hydroxynonenal (4HNE)