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[17] [18] Women at higher risk (e.g., those with diabetes, epilepsy, or a previous pregnancy affected by neural tube defects) should take a higher dose of 5 mg daily on prescription

First, we agree with the applicant that the LithoVue TM Elite Ureteroscope is used for one patient only, comes in contact with human tissue, and is surgically implanted or inserted or applied in or on a wound or other skin lesion

Lastly, the deheterochromatization level of facultative heterochromatin was observed to be lower in the 7588-year-old control group compared to the 2540-year-old one, which was expected