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Macrophage accumulation in human progressive diabetic nephropathy

Histological analysis confirmed marked peribronchial and parenchymal immune infiltration following AA exposure, along with significant epithelial thickening - both of which were markedly reduced by melatonin treatment ( Figures 1D-F )

10,11,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,345,346 Currently, drugs targeting BCAA uptake-dependent amino acid transporter LAT1 and metabolic enzymes BCAT and BCKDK are in trials

Kaplan Meier Overall survival (OS) of patients split based on ssGSEA scores for Glycolysis ( a ) and Fatty Acid (FA) metabolism ( b ) signatures, with Log rank test and Hazard Ratio analyses reported