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As with other glutathione peroxidases, GPx1 has a conserved catalytic tetrad composed of Sec or Cys, Gln, Trp, and Asn, where the Sec is surrounded by four arginines (R 57, 103, 184, 185

The disease can lead to numerous complications including damage to the heart and blood vessels, kidney disease, eye disease, nerve damage and premature death

Common injection sites include the abdomen, thigh, and upper arm