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One 72-week trial with a 20-week escalation found these results: 5 milligrams weekly: 15% weight reduction 10 milligrams weekly: 19.5% weight reduction 15 milligrams weekly: 20.9% weight reduction Further tirzepatide trials have been completed and show that with low-calorie diets and regular exercise, tirzepatide users can expect a total weight reduction of up to 26%

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"Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials"