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The American Academy of Allergy, Asthma & Immunology distinguishes a normal local reaction (redness or itching only at the injection point) from a hypersensitivity reaction

In an open-label RCT ( n = 96), oral administration of melatonin tablets (3 mg/d, 1 h before sleep, for 7 days) with standard treatment, substantially improved sleep quality and blood O 2 saturation parameters in hospitalized COVID-19 patients 667

We pair this with a comprehensive suite of biochemical and biophysical approaches including radioligand binding assays, receptor pharmacology, molecular dynamics simulations, and single-molecule biophysics to connect static structures to dynamic function

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