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In summary, our results reveal that various variants in LMNA , including two novel variants: LMNA (L35P) and LMNA (A539V), and two pathogenic LMNA variants LMNA (E358K) and LMNA (R453W) fish exhibit significantly weaker muscle strength compared to LMNA (WT) fish, which emphasize the impact of LMNA variants on muscle endurance in adult transgenic fish (Table 2)