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Tolerability remains a central issue across GLP-1 therapies, with gastrointestinal side effects common across the class

parkeri protein methyltransferases 1 and 2 (PkmT1 and PkmT2) methylate the lysines of surface outer membrane proteins (OMPs), which blocks ubiquitin targeting of these same lysines 44,45

There were no significant differences in GC or GS expression

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