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Previous reports suggest that A can be removed from the brain via various clearance systems (most importantly, the bloodbrain barrier (BBB))

For example, NQO1 also inhibits cytotoxic cytokines including IL-6, IL-1B, and TNF through TLR suppression in macrophages and microglia, a finding with clinical significance in both cancers and neurodegenerative disorders [49]

Therefore, careful system design is essential

Also, inoculation of potato with Potato virus Y (PVY) NTN that causes severe chlorotic/necrotic ringspots results in elevated expression of a GST , as compared to infections by the mild N strain (Kogovsek et al., 2010)