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The characteristics of heart rate increase appear to be: Dose-dependent : Higher doses generally produce greater increases Agent-specific : Some GLP-1 receptor agonists may have more pronounced effects than others Time-dependent : Heart rate changes typically occur early in treatment and may stabilise over time Clinically modest : The absolute increase is generally small and within normal physiological variation Proposed mechanisms for heart rate elevation include modulation of autonomic nervous system activity, with potential reduction in parasympathetic (vagal) tone or increase in sympathetic activity

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