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The type and severity of diabetes, the regulation of the glucometabolic state, blood sugar levels prior to physical activity, the kind of insulin or other hypoglycemic medications, and their final presumption for participation in sports are also pertinent

Recent research suggests that metformin may also alter the gut microbiota, through the protection of the intestinal barrier, promotion of SCFAs producing bacteria growth, regulation of bile acids plasmatic levels and their excretion, and direct regulation of growth of bacteria with a positive effect on glucose homeostasis (eg., Akkermansia muciniphila ) (Zhang and Hu, 2020)

The greater the weight regain, the more likely participants were to lose improvements in cholesterol and blood sugar levels