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Key Takeaways Dihexa's plasma half-life of 24 hours doesn't dictate dosing frequency because downstream synaptic changes persist 714 days after administration, substantially longer than compound detection in circulation

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Wilding JP, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MT, Wadden TA, Wharton S