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the best approach is one that can be maintained over time

Infiltration of M1-type macrophages into visceral fat leads to chronic release of pro-inflammatory cytokines, such as IL-1, which drive ovarian interstitial fibrosis and hemodynamic changes ( Metabolic dysfunction-associated steatotic liver disease is another prevalent metabolic comorbidity in obese women with PCOS

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Anionic liposomes, notably those made with glycerol or dendrimers, are widely recognized as safe and effective delivery vehicles because they have minimal toxicity and aid in the stability of nucleic acid drug therapies [80,81,82]