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The major pathological hallmarks of PD are represented by the progressive loss of dopamine(DA)-ergic neurons in the substantia nigra (SN) of the central nervous system (CNS) associated with cytoplasmic inclusions termed as Lewy bodies and Lewy neurites (Spillantini et al., 1997)

We do, however, have an idea about possible causes for the disorder

The MHRA product information for hydroxocobalamin preparations lists several recognised side effects that patients should be aware of before commencing treatment

Clinical implication Although the association between GLP-1 RAs and gallbladder/biliary diseases has been supported by multiple studies, causality has not been definitively established