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Risk factors for hemorrhage include the use of NSAIDs, lack of dietary fiber, constipation, and advancing age.10-12 Bleeding usually ceases spontaneously, with less than 1% of patients requiring greater than 4 units of blood.9 However, bleeding can become more hemodynamically significant in elderly patients with comorbid conditions, such as cerebrovascular disease or atherosclerotic cardiovascular disease, and in those with polypharmacy who may be taking anticoagulants or NSAIDs

Stacking multiple research compounds increases risk and makes attribution of effects (positive or negative) impossible

reactive microglia in postmortem PD brains, establishing one of the earliest links between neuroinflammation and PD

, 583 , 1358-1362, Pajula, R