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Interestingly, RT (3 sets of 812 repetitions progressing from 50%80% 1RM, 2 times per week) alone did not improve cognitive function in this study, nor did it exhibit synergistic effects with protein supplementation (Griffen et al., 2024)

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However, it is unclear which of these, the size increase or HSA binding, are more pharmacologically relevant and account for the observed extension of the half-life.47 Another approach is PEGylating which may destroy the activity in vitro but retain the efficacy in vivo.15 Human serum albumin (HSA) and IgG have plasma half-lives of around 21 days, owing to HSA and the Fc domain of IgG interacting with the neonatal Fc receptor expressed in blood vessel endothelial cells, which rescues the proteins in the endosomes after pinocytosis, preventing them from entering the lysosomal pathway for destruction