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Nicotine stimulates differentiation and specialization of cells in kidneys, the proliferation of mesangial cells, and fibronectin production, mediated through PKC activation, ERK1/2 phosphorylation, and NADPH oxidase and ROS generation [252, 292,293,294]

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Unlike traditional cigarettes, which burn tobacco to produce smoke, vaping devices heat the liquid, thereby eliminating combustion and reducing the release of harmful chemicals