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In a randomized, double-blind, placebo-controlled human trial, chronic supplementation with the NAD+ precursor nicotinamide riboside was well tolerated and effectively raised NAD+ metabolism in healthy middle-aged and older adults, with early signals toward lower blood pressure and arterial stiffness[1]

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This is closely associated with iron overload-mediated depression and abnormal glial cell activation (Zeng et al., 2023)

For males, lower baseline HbA1c levels were associated with increased likelihood of accomplishing glycemic control, whereas for females, history of previous management exclusively with metformin monotherapy was linked with lower probability of treatment failure (OR 0.321) [22]